1. Patient satisfaction result is based on cumulative data derived from the last completed questionnaire since the initial MammoSite clinical trial was initiated.
2. American Cancer Society, 2006
3. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis. National Cancer Center Policy Board. 2005.
4. King TA, et al. Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for Tis, 1,2, breast cancer. Am J Surg. 2000; 180:299-304.
5. Cytyc Surgical Products, Data on file.
6. Keisch M, Vicini F, Kuske R, et al. Initial clinical experience with the MammoSite breast brachytherapy applicator in early-stage breast cancer treated with breast conserving therapy. Intl J of Rad Onc*Bio*Phys, Vol 55, Num 2, 1 Feb 2003, 289-293.
7. The 5-year data is based on a median follow up of 63 months based on the 43 treated patients from the initial MammoSite clinical trial.
8. No local recurrences reported for 39 of the 43 treated patients. Local recurrence information was not available for 4 of the 43 treated patients.
9. Cosmetic results are based on 28 of the 43 treated patients from the initial MammoSite clinical trial. There were no poor cosmetic outcomes.
10. Fisher B, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. NEJM. 2002; 347:1233-1241.
11. Veronesi U, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. NEJM. 2002; 347:1227-1232.
12. Consensus statement for accelerated partial breast irradiation. The American Society of Breast Surgeons. December 8, 2005. Available at: http://www.breastsurgeons.org/apbi.shtml
13. Arthur D, Vicini F, et al. Accelerated partial breast irradiation: an updated report from the American Brachytherapy Society. Brachytherapy 2002; 184-190.
14. Vicini F, Beitsch P, et al. Two year analysis of treatment efficacy and cosmesis by the American Society of Breast Surgeons (ASBS) MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (ABPI). J Clin Onc, 2006
15. Streeter OE, Benitez P, Vicini F, et al. Partial breast irradiation for DCIS using MammoSite brachytherapy: a Phase II trial. Poster session presented at the 29th annual San Antonio Breast Cancer Symposium, Dec 14-17, 2006.
16. Fisher B, Bauer M, Margolese R, Poisson Pilch R, Y, Redmond C, Fisher E, Wolmark N, Deutsch M, Montague E, et al. Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. NEJM. 1985; 312 (11):665-673
17. Vicini FA, Beitsch PD, Quiet CA, et al. First analysis of patient demographics, technical reproducibility, cosmesis, and early toxicity. Cancer 2005; 104(6): 1138-1148.
18. Dowlatshahi K, Snider HC, Gittleman MA, et al. Early experience with balloon brachytherapy for breast cancer. Arch Surg. 2004; 139: 603-608.
19. Keisch M. MammoSite. Expert Review of Medical Devices 2005; 2(4): 387-394.
20. Benitez PR, Chen PY, Vicini FA, et al. Partial breast irradiation in breast-conserving therapy by way of interstitial brachytherapy. Amer. J Surgery 2004;188:355-364.
21. Keisch ME, Vicini F, Beitsch P, et al. Two year actuarial analysis of 194 patients with DCIS treated with Accelerated Partial Breast Irradiation (APBI): Efficacy, cosmesis and toxicity in patients on the American Society of Breast Surgeons (ASBS) MammoSite Breast Brachytherapy Registry Trial. International Journal of Radiation Oncology *Biology* Physics 2006; 66:3-Supplement.
22. Burstein HJ, Polyak K, Wong JS, et al. Ductal carcinoma in situ of the breast. N Engl J Med 2004; 350: 1430-1441.
23. Fisher B, Dignam J, Wolmark N, et al. Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: Findings from National Surgical Adjuvant Breast and Bowel Project B-17. J Clin Oncol 1998; 16(2): 441-452.
